A blood test for Sex Hormone Binding Globulin (SHBG) detects the presence of SHBG, a protein generated by the liver, in your bloodstream.

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The test is useful for assessing hormonal balance and health issues for numerous reasons:

Hormone Balance: The SHBG blood test is used to determine the balance of sex hormones, specifically testosterone and estradiol. SHBG binds to these hormones and influences their availability and action. Changes in SHBG levels might have an impact on the body’s overall hormonal balance.

Estimating Free Hormone Levels: By evaluating SHBG levels in conjunction with total hormone levels (for example, total testosterone), healthcare providers can estimate free, unbound hormone levels. Free hormones are hormones that are active and can interact with target tissues.

Hormone Imbalances: The SHBG test aids in the identification of hormonal imbalances caused by variables such as obesity, certain drugs, and hormonal illnesses. SHBG levels can be elevated in disorders such as polycystic ovarian syndrome (PCOS), and low in conditions such as hyperthyroidism.

Understanding Hormone-Related Conditions: Abnormal SHBG values can provide insight into sex hormone disruption conditions. The test assists in the diagnosis and treatment of various disorders.

Monitoring Hormone Replacement Therapy: The SHBG test can assist monitor the effects of hormone replacement therapy (HRT), such as for menopause or hypogonadism, and modify hormone dosages as needed.